Fig. 4

High chromatin accessibility at active genes correlates with histone modifications. a Heatmaps of ATAC-seq, ChIP-seq signal of active (H3K4me3) and repressive (H3K27me3) chromatin marks flanking (± 1 kb) TSS of genes ranked according to their expression level. b Browser view of a representative genomic locus (chromosome 1: 21,067,500–21,103,000). Black: ATAC-seq library with no significant peaks (see Fig. 2, NS). Blue: chromatin accessibility depicted by ATAC-seq. Red: H3K27me3 ChIP-seq profile. Green: H3K4me3 ChIP-seq profile. Purple: RNA-seq