Figure 4

Visualization of the expression of Nuclear Genes encoding Mitochondrial Proteins using MAPMAN. Pictorial representation of mitochondrial functions of the changes in gene expression from ModuleFinder as carried out in Figure 3B. The mitochondrial outer membrane contains the Translocase of the Outer Membrane (TOM) complex and the Translocase of the Inner Membrane 17:23 and 22 (TIM17:23 and TIM22) which are responsible for the import of all mitochondrial proteins synthesised in the cytosol [60]. The substrate carriers refer to the family of mitochondrial carrier proteins characterised by six transmembrane regions and responsible for the import and export of various metabolites in and out of mitochondria [61]. The mitochondrial electron transport chain consisting of four multi-subunit electron transport complexes and the ATP synthase complex are labelled I to V. The alternative electron transport chain components, alternative NAD(P)H dehydrogenases (NDH) and alternative oxidase (Aox) are shown. The TCA cycle and a range of other functions of mitochondria are listed [62]. The boxes represent the average gene expression for the 47 genes in Fig 3B divided into the functional annotation for these genes in Mapman.