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Table 4 Overview of strengths and weaknesses of the applied methods on different levels

From: High-throughput estimation of allele frequencies using combined pooled-population sequencing and haplotype-based data processing

 

MACE

GBS

WGS

Costs

Med

Low

High

Genes covered

Yes

Partly

Yes

Level

RNA

DNA

DNA

SNP count

Low

Med

High

Coverage

Varying

Med

Low

Genome representation

Biased

Biased

All

Sampling error

High

Low

Low

  1. MACE transcriptome sequencing, GBS enzyme-based genotyping by sequencing, WGS whole-genome resequencing (med = medium)