Skip to main content

Table 2 Obese mouse and rat models used in T2DM research

From: Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants

Model

Polygenic

Monogenic

References

Mouse

 db/db mouse

 

✓

[93]

 KK (Kuo Kundo) mouse

✓

 

[86, 94]

 KK AY (KK yellow obese) mouse

✓

 

[92]

 M16 mouse

✓

 

[86, 95]

 Nagoya-Shibata-Yasuda (NSY) mouse

✓

 

[96]

 New Zealand Obese (NZO) mouse

✓

 

[86]

 ob/ob mouse

 

✓

[93]

 Tsumura Suzuki obese diabetes (TSOD) mouse

✓

 

[97, 98]

Rat

 JCR/LA-cp (James C Russell/LA corpulent) rat

✓

 

[86]

 Otsuka Long-Evans Tokushima Fat (OLETF) rat

✓

 

[90]

 Spontaneously hypertensive rat/NIH-corpulent (SHR/N-cp) rat

 

✓

[86]

 Zucker Diabetic Fatty (ZDF) rat

 

✓

[86]

 Zucker fa/fa rat

 

✓

[86]

 Zucker Fatty Diabetes Mellitus (ZFDM) rat

 

✓

[99]