Fig. 2

The model of centromere-mediated chromosome elimination. According to the centromere-size model, CENH3-mediated HI involves cross between a wild-type line and a haploid inducer line with smaller/defective centromeres. A competitive loading process between WT and mutant CENH3s occurs during the hybrid formation. WT CENH3 may competitively load to all centromeres, thus generating a uniform centromere size and producing diploid progenies. In contrast, haploid inducer-derived centromeres may load with defective CENH3, generating smaller or defective centromeres, and they would be eliminated, producing haploid or aneuploid offspring